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Registro Completo |
Biblioteca(s): |
Embrapa Agricultura Digital; Embrapa Gado de Corte. |
Data corrente: |
17/07/2018 |
Data da última atualização: |
27/09/2018 |
Tipo da produção científica: |
Artigo em Periódico Indexado |
Autoria: |
ANDREOTTI, R.; GIACHETTO, P. F.; CUNHA, R. C. |
Afiliação: |
RENATO ANDREOTTI E SILVA, CNPGC; POLIANA FERNANDA GIACHETTO, CNPTIA; RODRIGO CASQUERO CUNHA, Bolsista PNPD/Capes. |
Título: |
Advances in tick vaccinology in Brazil: from gene expression to immunoprotection. |
Ano de publicação: |
2018 |
Fonte/Imprenta: |
Frontiers in Bioscience - Scholar, v. 10, n. 1, p. 127-142, Jan. 2018 |
Idioma: |
Inglês |
Conteúdo: |
Rhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis. |
Thesagro: |
Vacina. |
Thesaurus Nal: |
Gene expression; Rhipicephalus microplus; Transcriptome; Vaccines. |
Categoria do assunto: |
-- X Pesquisa, Tecnologia e Engenharia |
Marc: |
LEADER 01823naa a2200205 a 4500 001 2093371 005 2018-09-27 008 2018 bl uuuu u00u1 u #d 100 1 $aANDREOTTI, R. 245 $aAdvances in tick vaccinology in Brazil$bfrom gene expression to immunoprotection.$h[electronic resource] 260 $c2018 520 $aRhipicephalus (Boophilus) microplus has substantial economic impact on the cattle breeding industry and, chemical control and tick resistance development are the major concern. There is a worldwide search for new options, and control using vaccines has been the main focus nowadays. Studies performed in Brazil found that Bm86-based immunization of bovines reduced the infestation of R. (B.) microplus of vaccinated bovines by 45% to 60%. Native Boophilus microplus tripsin inhibitors (BmTIs) with trypsin-, kallikrein-, and elastase-inhibiting activities have been used as immunogens in bovines reaching 72.8.% of efficacy. The reverse vaccinology approach has also been used for antigen search using transcriptome analysis to identify and characterize potential antigens. Study has generated more than 600 million sequences using RNA-seq of larvae, nymphs, salivary glands, intestines, and ovaries of the tick R. (B) microplus. Based on the set of transcripts obtained using this strategy, a total of 20,326 protein sequences have been identified. A pipeline analysis built in house identified the protein sequences that were most likely to be immunogenic based on the overall structural characteristic analysis. 650 $aGene expression 650 $aRhipicephalus microplus 650 $aTranscriptome 650 $aVaccines 650 $aVacina 700 1 $aGIACHETTO, P. F. 700 1 $aCUNHA, R. C. 773 $tFrontiers in Bioscience - Scholar$gv. 10, n. 1, p. 127-142, Jan. 2018
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Registros recuperados : 124 | |
2. | | GIACHETTO, P. F. Transcriptoma do carrapato dos bovinos. In: ANDREOTI, R.; GARCIA, M. V.; KOLLER, W. W. (Ed.). Carrapatos na cadeia produtiva de bovinos. Brasília, DF: Embrapa, 2019. cap. 16, p. 205-222.Tipo: Capítulo em Livro Técnico-Científico |
Biblioteca(s): Embrapa Agricultura Digital. |
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3. | | ANDREOTTI, R.; GIACHETTO, P. F. Phylogenetic of phylogeographic relations of Rhipicephalus microplus ( Acari: ixodidae) in Brazil. In: AMERICAN ASSOCIATION OF VETERINARY PARASITOLOGISTS ANNUAL MEETING, 60.; LIVESTOCK INSECT WORKERS CON-FERENCE, 59.; INTERNATIONAL SYMPOSIUM ON ECTOPARASITES OF PETS, 13.,2015, Boston, MA. Parasitic Evolution Scientific Revolu-tion: Proceedings... Boston, MA: American Association of Veterinary Parasitologists, 2015. Resumo 146. 1 p.Tipo: Resumo em Anais de Congresso |
Biblioteca(s): Embrapa Gado de Corte. |
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5. | | GIACHETTO, P. F.; HIGA, R. H. Bioinformática aplicada à agricultura. In: MASSRUHÁ, S. M. F. S.; LEITE, M. A. de A.; LUCHIARI JUNIOR, A.; ROMANI, L. A. S. (Ed.). Tecnologias da informação e comunicação e suas relações com a agricultura. Brasília, DF: Embrapa, 2014. Cap. 4. p. 67-83.Tipo: Capítulo em Livro Técnico-Científico |
Biblioteca(s): Embrapa Agricultura Digital. |
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6. | | GIACHETTO, P. F.; HIGA, R. H. Bioinformatics applied to agriculture. In: MASSRUHÁ, S. M. F. S.; LEITE, M. A. de A.; LUCHIARI JUNIOR, A.; ROMANI, L. A. S. (Ed.). Information and communication technologies and their relations with agriculture. Brasília, DF: Embrapa, 2016. ch. 4, p. 67-86.Tipo: Capítulo em Livro Técnico-Científico |
Biblioteca(s): Embrapa Agricultura Digital. |
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Registros recuperados : 124 | |
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